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The pathogenesis of autism in relation to maternal antibodies: from molecule to connectome
Rusková, Lívia ; Jiruška, Přemysl (advisor) ; Míková, Hana (referee)
Autism is a neurological disease that affects predominantly boys. It is characterised by anti- social and stereotypical behaviour with a low level of empathy. Most of the studies have been focusing on the genetic aetiology of this disease, however in the past years research has focused on the role of maternal immune system. This thesis is putting together information predominantly about maternal autoimmune antibodies that recognize specific proteins important in neurogenesis. It is focusing on the function of these proteins in neurogenesis and their possible correlation with the pathological brain connectome in autism. Key words: autism, maternal antibodies, connectome, neurodevelopment
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The pathogenesis of autism in relation to maternal antibodies: from molecule to connectome
Rusková, Lívia ; Jiruška, Přemysl (advisor) ; Míková, Hana (referee)
Autism is a neurological disease that affects predominantly boys. It is characterised by anti- social and stereotypical behaviour with a low level of empathy. Most of the studies have been focusing on the genetic aetiology of this disease, however in the past years research has focused on the role of maternal immune system. This thesis is putting together information predominantly about maternal autoimmune antibodies that recognize specific proteins important in neurogenesis. It is focusing on the function of these proteins in neurogenesis and their possible correlation with the pathological brain connectome in autism. Key words: autism, maternal antibodies, connectome, neurodevelopment
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The role of immune system in autism
Niederlová, Veronika ; Otáhal, Jakub (advisor) ; Hájková, Michaela (referee)
Autism is a complex neurodevelopmental disorder with yet unknown etiology. The research point out abnormalities in the immune system of pacients with autism, which could be related to the development of the disease. This thesis reviews current scientific knowledge about the role of the immune system in the development of autism. The leading chapters include family history of autoimmune diseases, specific HLA alleles, the most common autoantibodies and maternal antibodies, lowered NK cell activity and cytokine levels in pacients with autism. Powered by TCPDF (www.tcpdf.org)
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